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APPLICATIONS

Applications

Back Scattering Interferometry (BSI) has broad application in life science research including small molecule drug discovery, biotherapeutic drug discovery, basic research, and mechanism of action studies.
Currently, MSI is focusing on drug discovery applications, specifically small molecule — complex target interaction characterization. MSI will publish data on additional applications in the near future, but in the meantime if you have specific research areas of interest that you would like to discuss, please contact us and we would be happy to review how BSI could support your efforts.

Learn more about BSI applications by clicking the links below:

ALLOSTERIC TARGETS

Direct binding quantification of low molecular weight ligands to ortho- and allosteric integral membrane protein and protein complex binding sites, under conditions where other technologies fail.

SECONDARY SCREENING

Direct binding confirmation of drug candidates from an HTS screen to the target of interest is critical to verification of a suspected MOA.

COMPLEX TARGETS

Complex drug targets for a large range of target classes have been successfully characterized in projects with major pharmaceutical companies.

Please send us an email or give us a call at (615) 938-7050 in North America or +49 (171) 760-4450 in Europe
to find out how MSI can help accelerate your assay development and screening efforts.

 

APPLICATIONS

  • ALLOSTERIC TARGETS
  • SECONDARY SCREENING & MECHANISM OF ACTION
  • COMPLEX TARGETS
  • TRUBIND AT WORK
    • ION CHANNEL INHIBITORS
    • KINASE INTERACTIONS
    • TARGETING GPCRs
    • PPI INTERACTIONS

ON-DEMAND WEBINARS

  • Interrogating Ligand: Target Interactions Using Back-Scattering Interferometry Yields Mechanistic Insight and Aids in Compound PrioritizationBy MSI on January 26, 2016
  • Review of Recent Publications Featuring Binding Data Produced by MSIBy MSI on January 26, 2016
  • Conformation-Sensitive Assay Detection for Accelerated Drug Discovery ResearchBy MSI on February 10, 2015
  • Evaluation of the MoA of Allosteric Modulators and Its Application to Drug Discovery using Back-Scattering InterferometryBy MSI on November 13, 2014
  • Using BSI to Investigate Positive Allosteric Modulators of the M4 ReceptorBy MSI on September 3, 2014

TRY A LOW-RISK, HIGH-RETURN DRUG DISCOVERY PROJECT

Take advantage of our success-based drug-target characterization services including ortho- and allosteric membrane bound proteins, receptors, ion channels, protein complexes — your toughest targets.
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