Nuovi Casino Online
Casinos Not On Gamstop
Non Gamstop Casinos
Non Gamstop Casinos
Trusted Non Gamstop Casinos 2025
Interrogating Ligand: Target Interactions Using Back-Scattering Interferometry Yields Mechanistic Insight and Aids in Compound Prioritization
Layton Harris Smith, PhD
Wednesday, February 3, 2016
Tweet
Transcript
Embed
Email
Bookmark
<<
<
>
>>
Chapters
Introduction
Cardioprotective effects of apelin
Apelin and its receptor (APJ)
Apelin maintains cardiac function in a mouse model of heart failure
uHTS for novel small molecule APJ agonists
APJ agonist uHTS stats
APJ Agonist Chemistry Summary
SBI-’692 is a potent small molecule agonist of APJ
SBI-’692 increases hiPSC-derived cardiac myocyte contractility
SBI-’692 increases contractility but not heart rate in vivo
APJ Agonists do not recapitulate
SBI-’692 is selective for APJ
Lead compounds compete for Ap13 binding
Back-scattering interferometry
Direct Ap13:APJ interaction as measured by BSI
Label-free ligand : target interaction analysis by BSI
Ligand mechanistic discrimination
Ap13 exhibits classic 2-state binding mode
GTPP(CH3)P reveals unique binding mode of SBI-692
Revised APJ agonist
Summary
Acknowledgments
Thank You
No transcript for this webinar
More Information
Request info
Similar interests
Casino Non AAMS
Non Gamstop Casinos
Gambling Sites Not On Gamstop
Casino Not On Gamstop
Casino Non AAMS
Best Non Gamstop Casinos